Solid state characterization, solid dispersions, solubility enhancement, drug dissolution and drug release
نویسندگان
چکیده
منابع مشابه
Drug - Drug Solid Dispersion: A Unique Approach in Solubility Enhancement
Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature in...
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One of the greatest challenges facing the pharmaceutical industry is the design and development of suitable delivery systems to overcome poor dissolution profile for insoluble drugs. Different formulation approaches including particulate systems, pH alterations and co solvents have been investigated in an attempt to determine the critical formulation parameters to improve dissolution and solubi...
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Mechanochemical activation is a practical cogrinding operation used to obtain a solid dispersion of a poorly water soluble drug through changes in the solid state molecular aggregation of drug-carrier mixtures and the formation of noncovalent interactions (hydrogen bonds) between two crystalline solids such as a soluble carrier, lactose, and a poorly soluble drug, indomethacin, in order to impr...
متن کاملAlbendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble compounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to improve their apparent solubilities under physiologically relevant conditions with surfactants as wetting agents. Albendazole (ABZ), one of the most effective...
متن کاملImproving Dissolution of Meloxicam Using Solid Dispersions
Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...
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ژورنال
عنوان ژورنال: Pharmaceutical Development and Technology
سال: 2017
ISSN: 1083-7450,1097-9867
DOI: 10.1080/10837450.2017.1275305